Sperm DNA damage emerges as key factor in repeated pregnancy loss
A Las Vegas fertility clinic used sperm DNA fragmentation testing to identify and treat a male partner’s DNA damage, leading to a successful birth after multiple miscarriages.
After five years of unsuccessful IVF attempts and repeated early pregnancy losses, a 32-year-old couple consulted Dr. Carrie Bedient at the Fertility Center of Las Vegas. Beyond standard semen analysis, Bedient ordered a sperm DNA fragmentation assay, which revealed a moderate level of damage. She advised the male partner to eliminate alcohol and tobacco, adopt regular exercise, and use vitamin supplements; his lifestyle changes reduced the DNA damage.
Six months later the couple produced healthy embryos and welcomed a baby boy. The American Society for Reproductive Medicine’s latest guidelines now mention that sperm DNA fragmentation testing may be considered in cases of recurrent miscarriage, though further research is still required. Experts such as Clarisa Gracia and Denny Sakkas emphasize that male health increasingly influences reproductive outcomes, and new sperm-sorting technologies are expanding treatment options. Recognizing the male role also aims to reduce stigma surrounding pregnancy loss.
Why it matters
Understanding male DNA damage can improve miscarriage treatment and reduce stigma around infertility.
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