Study Finds Sickle-Cell Mice Exhibit Prematurely Aged Blood Stem Cells
Researchers discovered that mice engineered to carry sickle-cell disease show blood-forming stem cells with signs of chronic stress, DNA damage and early aging, which can be reversed by certain cancer and anti-aging drugs.
Researchers discovered that mice engineered to carry sickle-cell disease show blood-forming stem cells with signs of chronic stress, DNA damage and early aging, which can be reversed by certain cancer and anti-aging drugs.
Why it matters
It reveals that approved drugs might counteract stem-cell aging in sickle-cell disease, opening new treatment possibilities.
In this story
sickle-cell diseasestem cellspremature agingDNA damagecancer drugsanti-aging treatmentsmouse modelcellular stresstherapeutic repurposing