Brief ultrasound session cuts delusions in schizophrenia trial
A single 10-minute transcranial ultrasound treatment lowered delusion scores in a small group of schizophrenia patients.
In a pilot study, scientists from NYU Langone Health used transcranial ultrasound stimulation to target the globus pallidus interna, a deep brain region involved in movement, thought and emotion. Ten men and women diagnosed with schizophrenia or schizoaffective disorder received a single 10-minute ultrasound session. Their delusion scores fell by an average of 1.2 points on a seven-point clinical rating, whereas a control group receiving a sham treatment showed no improvement.
Lead investigator Wei Qi described the findings as early evidence that non-invasive sound waves can safely modulate a brain circuit linked to psychosis. Reported adverse effects were limited to mild headaches, fatigue and brief increases in psychotic symptoms, all of which resolved quickly.
Why it matters
The study suggests a non-invasive, quick therapy could help patients whose psychotic symptoms persist despite medication.
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