Christina Applegate says doctors have ruled out multiple sclerosis after years of symptoms

Christina Applegate appeared on her Messy podcast with Jamie-Lynn Sigler to announce that a doctor has concluded she does not have multiple sclerosis, a disease she was diagnosed with in 2021. The 54-year-old actress, who has relied on a wheelchair and cane and spent months in a Los Angeles hospital, described the news as a “mind-fuck” and said it offers no relief from her worsening symptoms. She explained that the misdiagnosis forces her medical team to start a new inquiry into the cause of her ailments that have persisted for six years.

Applegate also spoke about the emotional toll, noting a deep depression and the loss of her acting work. She reiterated that she remains confined to a wheelchair for many daily tasks and continues to seek answers about her health.