Common Over-the-Counter Supplements May Unintentionally Reduce Sexual Desire

A health column outlines four over-the-counter supplements that might blunt sexual desire. Melatonin, frequently used in doses up to 20 mg for sleep, can affect the hypothalamic-pituitary-gonadal axis and suppress hormones such as luteinizing hormone, potentially reducing libido. Saw palmetto, taken for hair loss and benign prostatic hyperplasia, blocks the enzyme that converts testosterone to dihydrotestosterone, which may also lower sexual interest.

St. John’s wort, marketed for mood support, carries numerous drug interactions and is linked to erectile dysfunction, delayed orgasm and decreased drive, a point emphasized by pharmacist Ethan Melillo and the Mayo Clinic. Licorice root, commonly used for digestive issues, has been shown in some studies to lower testosterone and act as an anti-androgen. The article notes that scientific evidence is still emerging but suggests users reconsider regular use of these supplements if they notice a drop in desire.