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Home-based stool test linked to 43% drop in colorectal cancer deaths

Long-term data from Sweden show that people who complete an at-home colorectal cancer screening test face a 43% lower risk of dying from the disease.

A team from Karolinska Institutet and Umeå University examined the outcomes of the Stockholm-Gotland colorectal cancer screening initiative, which has been in place since 2008. The program sends free at-home kits to people aged 60-74 every two years, asking them to provide a stool sample for hidden-blood detection. Over a follow-up period of up to 14 years, the researchers followed 376,511 participants and observed 1,668 colorectal cancer deaths.

After adjusting for various biases, they found that simply being invited to screen lowered death risk by 26%, while actual test completion reduced it by 43%. The authors note that about one-third of invitees still do not submit a sample, underscoring the importance of participation. Funding came from the Swedish Cancer Society, the Swedish Research Council and Region Stockholm, and the investigators reported no conflicts of interest.

Why it matters

The findings highlight how a simple, free at-home test can dramatically improve survival from a common cancer.

In this story

colorectal cancerscreeningat-home testmortality reductionfecal occult bloodSwedenJAMA Network OpenKarolinska Institutet
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