Nanobody cocktail shows promise as a new snakebite antivenom in mouse trials
Researchers reported that a mixture of five nanobodies protected mice from lethal Indian cobra venoms, even when administered 20 minutes after exposure.
Scientists at the Technical University of Denmark evaluated a five-nanobody blend for its ability to neutralise venoms from Indian cobra species, building on earlier work with African snakes. Laboratory tests confirmed that all five nanobodies recognized toxins across multiple cobra venoms. In vivo, mice receiving the cocktail survived lethal doses that killed untreated controls within half an hour, and the treatment also averted paralysis and respiratory failure when given 20 minutes after venom injection.
Additional tests showed no binding to human proteins and retained activity after exposure to elevated temperatures, an advantage for distribution in rural areas. The study notes that the formulation does not protect against Indian kraits or vipers, indicating further development is needed before human trials. Nonetheless, the findings suggest nanobody-based antivenoms could become a more adaptable and affordable alternative to traditional horse-derived products.
Why it matters
Snakebite kills tens of thousands annually; a more effective, stable antivenom could save many lives, especially in rural regions.
In this story
