Oral microbiome transplants tested as cure for bad breath, cavities and mouth inflammation
Clinical trials are evaluating saliva-based microbiome transplants to treat halitosis, tooth decay and oral mucositis, with early results expected later this year.
Scientists are investigating oral microbiome transplants—transferring bacteria from healthy donors into patients—to address conditions such as halitosis, dental caries and oral mucositis. The University of Washington trial processes donor saliva into a saline solution used as a mouthwash or injected directly into gums; four volunteers have been treated and complete results are anticipated later this year. In Australia, Adelaide University identified 250 beneficial bacterial species that, when transplanted, may suppress cavity-causing microbes.
Separate studies have connected disrupted oral microbes to hand arthritis, early-onset bowel cancer and Parkinson’s-related dementia, indicating possible systemic effects. Experts like Dr Lindsey Edwards of King’s College London emphasize preserving good oral bacteria, noting that alcohol-based mouthwashes and excess alcohol can disturb the balance. Successful transplants could complement gut-microbiome therapies and provide new preventive options for a range of diseases.
Why it matters
Oral microbiome transplants could offer a novel, low-cost way to prevent common dental problems and potentially reduce risk of serious systemic diseases.
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