Rare genetic variant linked to dramatically higher lung cancer risk in never-smokers
Scientists have identified an extremely uncommon genetic mutation that raises the odds of lung cancer by about 25 times in people who have never smoked.
A new study appearing in the journal Science reports that a very rare genetic variant is associated with a 25-fold increase in lung cancer risk for individuals who have never smoked. Analysis of large-scale genetic data from 23andMe revealed that the variant is considerably more common among residents of Southern Appalachia in the United States compared with other areas. Experts caution that the mutation probably explains only a limited share of never-smoker lung cancer cases, yet it highlights the need to consider unique etiologies when designing screening programs and therapeutic strategies.
The research illustrates how massive health datasets can uncover narrow but crucial genetic links to disease. Overall, the work adds to growing evidence that lung cancer in never-smokers can arise from distinct biological factors.
Why it matters
Understanding a genetic cause of lung cancer in never-smokers could improve early detection and personalize treatment.
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