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Researchers unveil DNA-based computer that solves calculations using a water droplet

Scientists have built a DNA computer that performs calculations by exploiting the competitive binding of billions of molecules in a tiny drop of water.

A team from Maynooth University reported the creation of a Scaffolded DNA Computer that harnesses billions of DNA molecules in a microliter of salty water to perform logical operations. By designing competitive binding rules, DNA strands assemble on a larger scaffold, stabilising in the lowest-energy state that represents the correct answer. The researchers demonstrated ten programs, ranging from basic addition to 100-bit calculations, with simple tasks finishing in about half a minute and more complex sums requiring up to 14 hours.

The approach promises ultra-low-energy computing, potential molecular data storage, and operation inside living cells, though it remains far slower than conventional silicon processors. The system is also reusable, unlike many earlier molecular computers, and the team plans to improve scaffold designs and read-out methods for future applications.

Why it matters

It shows a viable path toward ultra-energy-efficient, bio-compatible computing and DNA-based data storage.

In this story

DNA computerscaffolded DNA computermolecular computingenergy-efficient computingDNA data storagethermodynamic computationbio-compatible devices
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